SAMe S-adenosylmethionine. Harv Rev Psychiatry. Delle Chiaie R, Pancheri P. Combined analysis of two controlled, multicentric, double blind studies to assess efficacy and safety of sulfo-adenosyl-methionine SAMe vs. G Ital Psicopatol. Int J Neuropsychopharmcol. S-adenosylmethionine treatment of depression: a controlled clinical trial. Am J Psychiatry. De Vanna M, Rigamonti R. Oral S-adenosyl-L-methionine in depression.
S-adenosylmethionine blood levels in major depression: changes with drug treatment. MC4: multicentre, controlled efficacy and safety trial of intramuscular S-adenosyl-methionine SAMe vs. Evaluation of S-adenosylmethionine in primary fibromyalgia.
A double-blind crossover study. Evaluation of S-adenosylmethionine in secondary fibromyalgia: a double-blind study. Clin Exp Rheumatol. The clinical potential of ademetionine S-adenosylmethionine in neurological disorders. Striatal dopamine depletion, tremors, and hypokinesia following the intracranial injection of S-adenosylmethionine: a possible role of hypermethylation in parkinsonism.
Mol Chem Neuropathol. S-adenosylmethionine treatment of depression in patients with Parkinson's disease: a double-blind, crossover study versus placebo. Reproductive toxicity studies of ademetionine.
Berger R, Nowak H. A new medical approach to the treatment of osteoarthritis: report of an open phase IV study with ademetionine Gumbaral.
Konig B. A long-term two years clinical trial with S-adenosylmethionine for the treatment of osteoarthritis. Lack of mutagenic activity of ademetionine in vitro and in vivo.
Br J Psychiatry. Switch and S-adenosylmethionine. Ala J Med Sci. Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial. Toxic interaction of S-adenosylmethionine and clomipramine [letter]. A double-blind, randomized parallel-group, efficacy and safety study of intramuscular S-adenosyl-L-methionine 1,4-butanedisulphonate SAMe versus imipramine in patients with major depressive disorder.
Int J Neuropsychopharmacol. S-adenosyl methionine SAMe versus celecoxib for the treatment of osteoarthritis symptoms: A double-blind cross-over trial. BMC Musculoskelet Disord. Efficacy of combined use of ursodeoxycholic acid and heptral in the treatment of primary biliary cirrhosis. Klin Med Mosk. Ursodeoxycholic acid, S-adenosyl-L-methionine and their combinations in the treatment of gestational intrahepatic cholestasis ICP.
Ceska Gynekol. Interventions for treating cholestasis in pregnancy. Cochrane Database Syst Rev. A randomised controlled trial of ursodeoxycholic acid and S-adenosyl-l-methionine in the treatment of gestational cholestasis. S-adenosyl methionine SAMe augmentation of serotonin reuptake inhibitors for antidepressant nonresponders with major depressive disorder: a double-blind, randomized clinical trial.
Improvement of aggressive behavior and quality of life impairment following S-adenosyl-methionine SAM-e augmentation in schizophrenia. Eur Neuropsychopharmacol. Evidence for the efficacy of complementary and alternative medicines in the management of osteoarthritis: a systematic review. Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
All rights reserved. Depression ; Osteoarthritis. Therapeutic Dosages. Therapeutic Uses. Interactions You Should Know About. P1 The body makes all the SAMe it needs, so there is no dietary requirement. P2 A typical full dosage of SAMe is mg taken 3 to 4 times per day. John's wort is by far the most studied alternative remedy for depression, and for the most part the results have been favorable. In studies involving people with mild to moderate depression, St.
John's wort has consistently outperformed placebo, and it has held its own against prescription antidepressants. It has been shown to be similarly effective -- and in a few cases, more effective -- than fluoxetine Prozac , imipramine, and Celexa. The effectiveness of St. John's wort in more severe cases of depression has been questioned, however. A highly publicized study of people with "moderately severe" depression published in JAMA in found that neither St.
John's wort nor sertraline Zoloft were significantly more effective than a placebo. Due to this and other trials, it is generally recommended only for milder cases of depression. The bottom line: For mild -- but only mild -- cases of depression, its effectiveness may rival that of antidepressants.
The Natural Standard Research Collaboration has given the evidence supporting its use for mild depression an "A"; for severe depression, a "D". John's wort generally has few side effects, but it can interact with other drugs, so -- as with any supplement -- check with your doctor before trying it.
What it is: An amino acid -- most famous for being found in Thanksgiving turkey -- that helps produce serotonin, the neurotransmitter targeted by drugs such as Prozac SSRIs. It is sold over-the-counter in capsule form as L-tryptophan and 5-HTP, which represent different stages in the serotonin production process.
The evidence: Studies have shown a connection between tryptophan depletion and depressive symptoms especially in women , but the evidence for the use of tryptophan supplements is thin.
A review of tryptophan studies that examined more than trials found only two that were of high quality and did not include other supplements. Tryptophan did outperform placebo in those studies, but the studies were small. There are some concerns about the safety of tryptophan supplements, which have been found to contain impurities and contaminants.
In , the U. Food and Drug Administration FDA temporarily pulled all L-tryptophan products off the market after more than 1, people who took L-tryptophan supplements developed a blood disorder called eosinophilia myalgia syndrome. Ultimately, more than two dozen people died. The bottom line: The overall evidence is inconclusive and safety concerns persist, although the authors of the review did note that tryptophan could play a role in patients with mild cases of depression who can't or don't want to take antidepressant drugs.
Copyright Health Magazine Share this on:. EPA and DHA, essential to brain function and cardiovascular health, are the main ingredients in fish oil.
Most Popular. Fine art from an iPhone? The best Instagram photos from After IVF shock, mom gives birth to two sets of identical twins. Inside North Korea: Water park, sacred birth site and some minders. What really scares terrorists. While many people have no untoward reactions, some people do experience diarrhea, abdominal discomfort, nausea, or vomiting.
Even though SAMe is sold without a prescription, you should consult with your doctor about your depression rather than simply try to treat yourself. Like most supplements, SAMe is not covered by most insurance. SAMe supplements are generally sold in pill or tablet form.
Sign up for our newsletter to get the best of Tonic delivered to your inbox. Sign In Create Account. June 29, , pm. What is SAMe? Would my psychiatrist actually recommend a natural supplement for depression?
Does the brand of SAMe make a difference in how effective it is? What type of dose would I start with? Are there any risks and should I keep my doctor in the loop?
Is SAMe covered by my insurance? Tagged: Health mental health research Same antidepressant mind supplements Tonic sude effects.
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